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  • (PDF) Roles of zinc and copper in modulating the oxidative ...

    copper-reconstituted superoxide dismutase as a function of copper content. Apo-SOD1, E,Zn-SOD1, and Cu,E-SOD1 w ere achieved by the methods as described in 'Materials and Methods'.

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  • Free Fatty Acids, Lipopolysaccharide and IL-1α Induce ...

    Excess fat storage in adipocytes is associated with increased generation of reactive oxygen species (ROS) and impaired activity of antioxidant mechanisms. Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme involved in detoxification of ROS, and objective of the current study is to analyze expression and regulation of MnSOD in obesity.

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  • (PDF) Superoxide dismutase activity in colostrum ...

    The specific activity of manganese superoxide dismutase (MnSOD) and copper, zinc (CuZn)SOD in the colostral phase (3-5 days), the third week, and the fourth and sevenths month of lactation.

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  • (PDF) Pro-oxidant activity of Cu,Zn-superoxide dismutase

    The superoxide dismutase (SOD) activity of bovine copper-zinc superoxide dismutase (Cu,Zn-SOD) in 50 mM Hepes [4-(2-hydroxyethyl)-1- piperazineethanesulfonic …

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  • A review of fatty acid profiles and antioxidant content in ...

    2010-3-10u2002·u2002Review of fatty acid profiles in grass-fed beef. Red meat, regardless of feeding regimen, is nutrient dense and regarded as an important source of essential amino acids, vitamins A, B 6, B 12, D, E, and minerals, including iron, zinc and selenium [17,18].Along with these important nutrients, meat consumers also ingest a number of fats which are an important source of energy …

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  • (PDF) Blood antioxidant profile and lipid peroxides in ...

    and SCC recorded in milk of mastitic cows were 3.67 revealed a significant decrease in GSH concentration. 5. ±0.13 and 83.12±1.17 x 10 per ml respectively. Out of in mastitic cows …

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  • (PDF) Industrial Production of Superoxide Dismutase (SOD ...

    Superoxide dismutase (SOD) and Pero xidases are enzymatic whether. glutathione, carotenoids, vitamins A, C and E etc. are non-enzymatic. e enzymatic mechanism is the …

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  • Prognostic potential of pre-partum blood biochemical and ...

    2020-5-14u2002·u2002Higher serum concentrations of superoxide dismutase (P < 0.01) and lower malondialdehyde levels (P < 0.01) in low SCC than in high SCC cows indicate that the latter suffered from oxidative stress. The difference analysis of the three groups suggested that none of the above-mentioned variables can be used as potential prognostic candidates.

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  • (PDF) Analysis of Phenolic Content and Antioxidant ...

    2015-12-14u2002·u2002Analysis of Phenolic Content and Antioxidant Properties of Selected Cowpea Varieties Tested in Bovine Peripheral Blood December 2015 American Journal of Animal and Veterinary Sciences 10(4):235-245

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  • Manganese Superoxide Dismutase (MnSOD) and Its Importance ...

    2016-10-14u2002·u2002Manganese superoxide dismutase (MnSOD) is an essential antioxidant enzyme localized in mitochondria. MnSOD protects the cell from the harmful effects of ROS, in general, and guards against mitochondrial dysfunction, in particular.

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  • Dual gene therapy with extracellular superoxide dismutase ...

    2007-1-5u2002·u2002ROS scavengers include catalase and superoxide dismutase (SOD). SOD dismutes superoxide to hydrogen peroxide (H 2 O 2) and catalase detoxifies the H 2 O 2 to H 2 O and O 2. In a prior study, we targeted a single ROS, hydrogen peroxide, for detoxification by catalase gene inoculationn . It reduced demyelination of the optic nerve by 38%.

    Get Price
  • Defective hematopoiesis and hepatic steatosis in mice with ...

    2001-8-15u2002·u2002Several lines of evidence point to an abnormality in the response of Fanconi anemia cells to reactive oxygen species. To investigate the potential pathologic consequences of an in vivo alteration of redox state in mice lacking one of the Fanconi anemia genes, animals were generated having combined deficiencies of the cytosolic Cu/Zn superoxide dismutase (Sod1) and Fanconi …

    Get Price
  • THERAPEUTIC ANTI-MICROBIAL OXIDATIVE RESPONSES IN

    2020-12-4u2002·u2002Progress 10/01/98 to 09/30/04 Outputs The intent of the proposal was to characterize the pro- and anti-oxidant responses in cows' milk with a view towards enhancing defence of the mammary gland against pathogens that cause mastitis. Cow's milk was found to contain large amounts of pro-oxidant enzymes xanthine oxidase and myeloperoxidase, as well as the anti …

    Get Price
  • Superoxide Dismutases: Role in Redox Signaling, Vascular ...

    2019-9-9u2002·u2002Excessive reactive oxygen species Revised abstract, especially superoxide anion (O 2 •−), play important roles in the pathogenesis of many cardiovascular diseases, including hypertension and atherosclerosis.Superoxide dismutases (SODs) are the major antioxidant defense systems against O 2 •−, which consist of three isoforms of SOD in mammals: the cytoplasmic …

    Get Price
  • Antiobesity, hepatoprotective and anti-hyperglycemic ...

    In addition, catalase (Beutler, 1975) and superoxide dismutase activity (Winterbourn et al., 1984) were also determined. 2.10. Biochemical analysis. Blood samples were collected by cardiac puncture, and serum was obtained by centrifuging.

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  • Antioxidative factors in milk - Cambridge

    Antioxidative factors in milk Helena Lindmark-Ma˚nsson1,2* and B. A˚ kesson2 1Swedish Dairy Association, Scheeleva¨gen 18, SE-223 63 Lund, Sweden 2Division of Biomedical Nutrition, Center for Chemistry and Chemical Engineering, Lund University, SE-221 00 Lund, Sweden Lipid auto-oxidation in milk is affected by a complex interplay of pro- and antioxidants.

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  • A High-Fat, High-Fructose Diet Induces Antioxidant ...

    2016-2-2u2002·u2002Excessive fat liver is an important manifestation of nonalcoholic fatty liver disease (NAFLD), associated with obesity, insulin resistance, and oxidative stress. In the present study, the effects of a high-fat, high-fructose diet (HFFD) on mRNA levels and activities of the antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase …

    Get Price
  • Effects of Huangjiu, Baijiu and Red Wine Combined With ...

    Chronic drinking when combined with HFD was associated with reduced body weight, fat accumulation and serum TNF-α level, serum TG, TC and LDL-C levels, and improved glucose tolerance (OGTT) and insulin sensitivity (ITT), hepatic enzymes; elevated levels or activities of the antioxidant enzymes like superoxide dismutase, catalase and glutathione reductase, reduced the …

    Get Price
  • Natural and Artificial Beverages: Exploring the Pros and ...

    2019-1-1u2002·u2002With low sugar and low fat content these drinks ensure the stabilization of blood sugar and body weight. Drinking these drinks helps to detoxify our body from harmful radicals. These beverages prevent heart attack by relaxing the blood vessels and inhibiting blood clotting that leads to heart attack (myocardial infarction).

    Get Price
  • Potential Role of Endoplasmic Reticulum Stress in ...

    2015-12-31u2002·u2002Diabetes mellitus is a metabolic disease that leads to several complications which include retinopathy. Multiple biochemical abnormalities have been proposed to explain the development of retinopathy, including oxidative stress. Although the existence of oxidative stress has been established in the retina from long standing diabetic animals, pathogenesis and …

    Get Price
  • 20655 - Gene ResultSod1 superoxide dismutase 1, soluble ...

    2021-9-12u2002·u2002superoxide dismutase 1 expression and activity is affected by low dose radiation in a diabetes model Copper-zinc superoxide dismutase deficiency impairs sperm motility and in vivo fertility. Results highlight misfolded SOD1 as common to two Amyotrophic lateral sclerosis (ALS) rodent animal models and familial ALS patient lymphoblasts with four ...

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  • Nitric oxide, superoxide, and peroxynitrite: the good, the ...

    2020-3-5u2002·u2002Nitric oxide is removed within seconds in vivo by diffusion over 100 microns through tissues to enter red blood cells and react with oxyhemoglobin. The direct toxicity of nitric oxide is modest but is greatly enhanced by reacting with superoxide to form peroxynitrite (ONOO-).

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  • Appropriate Methods of Diagnosing Mineral Deficiencies in ...

    2019-8-16u2002·u2002Copper deficiency can be diagnosed via analysis of copper-containing enzymes. The two most common enzymes that are utilized are ceruloplasmin and superoxide dismutase (Suttle, 1986; Mills, 1987). Low concentrations of these enzymes in serum and whole blood, respectively, are diagnostic for copper deficiency.

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  • Antioxidative factors in milk - Cambridge

    Antioxidative factors in milk Helena Lindmark-Ma˚nsson1,2* and B. A˚ kesson2 1Swedish Dairy Association, Scheeleva¨gen 18, SE-223 63 Lund, Sweden 2Division of Biomedical Nutrition, Center for Chemistry and Chemical Engineering, Lund University, SE-221 00 Lund, Sweden Lipid auto-oxidation in milk is affected by a complex interplay of pro- and antioxidants.

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  • Oxidative Stress in Mice Fed a High-Fat Diet

    2017-5-9u2002·u2002(TB) added to a high–fat diet on the development of obesity and oxidative stress. CF-1 mice were fed a standard low-fat (LF) diet, a 60% high-fat diet (HF) and HF diets containing either 0.5% AR extract (HF-AR), 10% TB (HF-TB), or 0.5% vitamin E …

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  • Antihyperglycemic activity of Selaginella tamariscina ...

    Materials and methods. HepG2 cells and type II diabetic rats induced by low-dose streptozotocin (STZ) and high-fat diet (HFD) were used to evaluate the hypoglycemic effect of EtOH and H 2 O extracts of Selaginella tamariscina.HepG2 cells were used to evaluate the promotive effect of different fractions of EtOH extract obtained from a polyamide column on glucose utilization.

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  • Hepatoprotective effects of flavonoids from common ...

    high-sugar and high-fat diets (Composition: 10% lard, 10% sucrose and 5% cholesterol) for 4 weeks with some modifications according to Zhang et al. (2008). Rats gradually showed polyphagia, polydipsia, and polyuria, with low spirits and yellow coat color. The glucose level was measured from the tail vein blood using glucose oxidase method with

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  • Sulphadoxine-pyrimethamine alters the antioxidant defense ...

    2017-5-26u2002·u2002enzymes such as superoxide dismutase (SOD), glutathione peroxidase and catalase (CAT); fat soluble vitamins A and E; as well as water soluble, low molecular weight substances such as vitamin C, glutathione (GSH) and carotenoids (Akkus et al., 1996). SOD promotes the dismutation of superoxide anion (O 2

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  • Amitraz induced cytotoxic effect on bovine cumulus cells ...

    2021-2-7u2002·u2002The aim of this study was to evaluate the genotoxic and cytotoxic effects of amitraz (AMZ) on the primary culture of bovine cumulus cells (CC) and oocyte nuclear maturation. Cytotoxicity was evaluated by assessing mitochondrial activity with the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Genotoxicity was estimated using …

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  • A Safe, Non-Drug, Natural Approach to Attention Deficit ...

    Scores of published human studies, including double-blind clinical trials, establish that Flavay Plus® increases blood flow, improves nitric oxide levels and neurotransmitter activities, improves glucose metabolism in brain cells (all of which is essential to learning, memory and other cognitive functions) and thereby:. strengthens memory, (168, 126, 213)

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  • Dual gene therapy with extracellular superoxide dismutase ...

    2007-1-5u2002·u2002ROS scavengers include catalase and superoxide dismutase (SOD). SOD dismutes superoxide to hydrogen peroxide (H 2 O 2) and catalase detoxifies the H 2 O 2 to H 2 O and O 2. In a prior study, we targeted a single ROS, hydrogen peroxide, for detoxification by catalase gene inoculationn . It reduced demyelination of the optic nerve by 38%.

    Get Price
  • Defective hematopoiesis and hepatic steatosis in mice with ...

    2001-8-15u2002·u2002Several lines of evidence point to an abnormality in the response of Fanconi anemia cells to reactive oxygen species. To investigate the potential pathologic consequences of an in vivo alteration of redox state in mice lacking one of the Fanconi anemia genes, animals were generated having combined deficiencies of the cytosolic Cu/Zn superoxide dismutase (Sod1) and Fanconi …

    Get Price
  • THERAPEUTIC ANTI-MICROBIAL OXIDATIVE RESPONSES IN

    2020-12-4u2002·u2002Progress 10/01/98 to 09/30/04 Outputs The intent of the proposal was to characterize the pro- and anti-oxidant responses in cows' milk with a view towards enhancing defence of the mammary gland against pathogens that cause mastitis. Cow's milk was found to contain large amounts of pro-oxidant enzymes xanthine oxidase and myeloperoxidase, as well as the anti …

    Get Price
  • Superoxide Dismutases: Role in Redox Signaling, Vascular ...

    2019-9-9u2002·u2002Excessive reactive oxygen species Revised abstract, especially superoxide anion (O 2 •−), play important roles in the pathogenesis of many cardiovascular diseases, including hypertension and atherosclerosis.Superoxide dismutases (SODs) are the major antioxidant defense systems against O 2 •−, which consist of three isoforms of SOD in mammals: the cytoplasmic …

    Get Price
  • Antiobesity, hepatoprotective and anti-hyperglycemic ...

    In addition, catalase (Beutler, 1975) and superoxide dismutase activity (Winterbourn et al., 1984) were also determined. 2.10. Biochemical analysis. Blood samples were collected by cardiac puncture, and serum was obtained by centrifuging.

    Get Price
  • Antioxidative factors in milk - Cambridge

    Antioxidative factors in milk Helena Lindmark-Ma˚nsson1,2* and B. A˚ kesson2 1Swedish Dairy Association, Scheeleva¨gen 18, SE-223 63 Lund, Sweden 2Division of Biomedical Nutrition, Center for Chemistry and Chemical Engineering, Lund University, SE-221 00 Lund, Sweden Lipid auto-oxidation in milk is affected by a complex interplay of pro- and antioxidants.

    Get Price
  • A High-Fat, High-Fructose Diet Induces Antioxidant ...

    2016-2-2u2002·u2002Excessive fat liver is an important manifestation of nonalcoholic fatty liver disease (NAFLD), associated with obesity, insulin resistance, and oxidative stress. In the present study, the effects of a high-fat, high-fructose diet (HFFD) on mRNA levels and activities of the antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase …

    Get Price
  • Effects of Huangjiu, Baijiu and Red Wine Combined With ...

    Chronic drinking when combined with HFD was associated with reduced body weight, fat accumulation and serum TNF-α level, serum TG, TC and LDL-C levels, and improved glucose tolerance (OGTT) and insulin sensitivity (ITT), hepatic enzymes; elevated levels or activities of the antioxidant enzymes like superoxide dismutase, catalase and glutathione reductase, reduced the content …

    Get Price
  • Natural and Artificial Beverages: Exploring the Pros and ...

    2019-1-1u2002·u2002With low sugar and low fat content these drinks ensure the stabilization of blood sugar and body weight. Drinking these drinks helps to detoxify our body from harmful radicals. These beverages prevent heart attack by relaxing the blood vessels and inhibiting blood clotting that leads to heart attack (myocardial infarction).

    Get Price
  • Potential Role of Endoplasmic Reticulum Stress in ...

    2015-12-31u2002·u2002Diabetes mellitus is a metabolic disease that leads to several complications which include retinopathy. Multiple biochemical abnormalities have been proposed to explain the development of retinopathy, including oxidative stress. Although the existence of oxidative stress has been established in the retina from long standing diabetic animals, pathogenesis and …

    Get Price
  • Prognostic potential of pre-partum blood biochemical and ...

    2020-5-14u2002·u2002Higher serum concentrations of superoxide dismutase (P < 0.01) and lower malondialdehyde levels (P < 0.01) in low SCC than in high SCC cows indicate that the latter suffered from oxidative stress. The difference analysis of the three groups suggested that none of the above-mentioned variables can be used as potential prognostic candidates.

    Get Price
  • Methods for detection of reactive metabolites of oxygen ...

    2019-10-30u2002·u2002the discovery by McCord and Fridovich (83, 84) that the erythrocyte-associated enzyme superoxide dismutase (SOD) decomposes the free radical superoxide launched a frenzy of research activity that remains unabated over the past 35 years.Indeed, the discovery of SOD defined an entirely new area of biomedical research that represents one of the fundamental advances in biology over the …

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  • A review of fatty acid profiles and antioxidant content in ...

    2010-3-10u2002·u2002Growing consumer interest in grass-fed beef products has raised a number of questions with regard to the perceived differences in nutritional quality between grass-fed and grain-fed cattle. Research spanning three decades suggests that grass-based diets can significantly improve the fatty acid (FA) composition and antioxidant content of beef, albeit with variable impacts on overall palatability.

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  • Effects of acute dimethoate administration on antioxidant ...

    2005-1-5u2002·u2002As shown in Table 1, superoxide dismutase activity was recorded to be increased in treated groups as compared with control group.It increased significantly at 90 and 75. mg/kg doses in brain and liver, respectively.. Similarly, the catalase activity was also found to be significantly increased in liver and brain at doses 90 and 75 mg/kg.Glutathione peroxidase activity increased significantly ...

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  • Combination of probiotic and phythobiotic as an ...

    2021-3-27u2002·u2002The use of a combination of herbs and probiotics has also been reported to increase crude protein content, reduce crude fat content, and can reduce lipid oxidation in broiler chicken meat (Sarker et al 2010; Hossain et al 2012). The low value of lipid oxidation indicates that there is an increase in oxidative stability in broiler meat.

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  • Antioxidant and anti‑inflammatory effects of

    2017-9-21u2002·u2002It has been shown that oxidative damage and inflammation caused by hyperglycemia in endothelial cells are key factors triggering diabetic vascular complications. The aim of the present study was to investigate the antioxidant and anti‑inflammatory effects of Danhong Huayu Koufuye (DHK)‑medicated serum on high glucose (HG)‑induced injury in endothelial cells, and examine its …

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  • Journal Home

    Aurora Kinase B Expression, Its Regulation and Therapeutic Targeting in Human Retinoblastoma Open Access. Naheed Arfin Borah Swatishree Sradhanjali, Manas Ranjan Barik, et al. Physiology and Pharmacology. NCX 667, a Novel Nitric Oxide Donor, Lowers Intraocular Pressure in Rabbits, Dogs, and Non-Human Primates and Enhances TGFβ2-Induced Outflow ...

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  • Effect of whey protein on blood lipid profiles: a meta ...

    2016-3-30u2002·u2002The effect of a low-fat, high-protein or high-carbohydrate ad libitum diet on weight loss maintenance and metabolic risk factors. Int J Obes 2009; 33 : 296–304. CAS Article Google Scholar

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  • Differences in the Expression of Heat-Shock Proteins and ...

    1995-11-1u2002·u2002It has previously been observed that the insulin-producing cells of human pancreatic islets are more resistant to alloxan-, streptozotocin-, nitroprusside-, or cytokine-induced injury than those of mouse and rat islets. Human pancreatic islets were obtained from heart-beating organ donors. The expression of the stress proteins heat shock protein 70 (hsp70) and heme oxygenase and the anti ...

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  • Oxidative Stress, Inflammation, and Disease - ScienceDirect

    2016-1-1u2002·u2002Oxidative stress is a term coined to denote the state of imbalance between the generation of oxidants (ie, free radicals and ions collectively called reactive oxygen species (ROS) and the availability of endogenous antioxidants to scavenge this ROS resulting in an excess production of oxidants [1], [2], [3]. As this ROS produced in biological ...

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  • Lipid peroxides, superoxide dismutase and circulating IL-8 ...

    2005-6-30u2002·u2002The range of the standard curve was 0.1 to 5 μM per milliliter blood serum. Superoxide dismutase activity assay. SOD enzymatic activity was measured as previously described, using reagents from Sigma. SOD from bovine erythrocytes was used in constructing the standard curve, which ranged from 15–750 mU).

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  • Lymphocyte enzymatic antioxidant responses to

    2010-5-26u2002·u2002effects within the cellular environment. For instance, low concentrations of ROS upregulate the expression of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in skeletal muscle (15). Catalase (CAT), SOD, and GPX present in mononuclear cells scavenge both exogenous and endogenous ROS. Additionally, lymphocyte SOD and GPX activities in-

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  • Antioxidant and anti‑inflammatory effects of

    2017-9-21u2002·u2002It has been shown that oxidative damage and inflammation caused by hyperglycemia in endothelial cells are key factors triggering diabetic vascular complications. The aim of the present study was to investigate the antioxidant and anti‑inflammatory effects of Danhong Huayu Koufuye (DHK)‑medicated serum on high glucose (HG)‑induced injury in endothelial cells, and examine its …

    Get Price
  • Glucose-sensing microRNA-21 disrupts ROS homeostasis

    2018-7-23u2002·u2002Antioxidant enzymes play a fundamental role in counteracting oxidative stress induced by high glucose. Although mitochondrial superoxide dismutase (SOD2) is the principal defence against the toxicity of superoxide anions, the mechanism of its inactivation in diabetic subjects is still poorly understood. Recently, microRNA-21 has been associated with diabetes, although its function remains …

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  • RESEARCH Open Access Onion peel extracts ameliorate ...

    2017-8-27u2002·u2002superoxide dismutase activity and malondialdehyde formation, plasma free fatty acids, and hepatic protein expressions of IL-6 were significantly reduced by 1% OPE administration (P = 0.0393, 0.0237, 0.0148 and 0.0025, respectively). Conclusion: OPE might improve glucose response and insulin resistance associated with type 2 diabetes by

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  • REVIEW Open Access A review of fatty acid profiles and ...

    2017-8-28u2002·u2002REVIEW Open Access A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef Cynthia A Daley1*, Amber Abbott1, Patrick S Doyle1, Glenn A Nader2, Stephanie Larson2 Abstract Growing consumer interest in grass-fed beef products has raised a number of questions with regard to the per-

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  • Apigenin in the regulation of cholesterol metabolism and ...

    blood fat, reduced animal weight, and reduced total cholesterol (P=0.024), triglyceride (P=0.031) and low-density lipoprotein cholesterol (P=0.014) in the serum of the high-fat diet mice. Apigenin improved the blood lipid metabolism of the hyper-lipidemia model mice. Body weight and serum cholesterol

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  • Mohsen Zommara

    The peroxidation stress was evaluated by reduction of the activities of the antioxidative enzymes superoxide dismutase (SOD), catalase, glutathione peroxidase (GSHPX) in liver and the activity of catalase in red blood cells (RBC), increasing thiobarbituric acid reactive substances (TBARS) in RBC and reduction of vitamin E concentration in plasma.

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  • Effect of whey protein on blood lipid profiles: a meta ...

    2016-3-30u2002·u2002The effect of a low-fat, high-protein or high-carbohydrate ad libitum diet on weight loss maintenance and metabolic risk factors. Int J Obes 2009; 33 : 296–304. CAS Article Google Scholar

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  • Amazon.com: Biotics Research Cytozyme Orchic Contains

    Orchic Concentrate (bovine), Superoxide Dismutase (from vegetable culture†), Catalase (from vegetable culture†) † Specially grown, biologically active vegetable culture containing naturally associated phytochemicals including polyphenolic compounds with SOD and catalase, dehydrated at low temperature to preserve associated enzyme factors.

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