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  • Superoxide Dismutase Archives - Randox Laboratories

    2016-10-20u2002·u2002Superoxide Dismutase. Superoxide is a by-product of oxygen metabolism and is one of the most damaging free radicals in the body as it can cause cell damage. Superoxide Dismutase (SOD) is an enzyme which catalyses the breakdown of superoxide into a less damaging oxygen or hydrogen peroxide.

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  • A superoxide dismutase/catalase mimetic nanomedicine for ...

    2016-10-1u2002·u2002Superoxide, peroxide, and hydroxyl radical are among the major components of ROS . Most intracellular ROS are derived from superoxide that is generated by the reduction of oxygen. Dismutation of superoxide by superoxide dismutase (SOD) generates hydrogen peroxide, which may be reduced to hydroxyl radical or decomposed into water by catalase.

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  • Activity, thermostability and isozymes of superoxide ...

    2012-5-1u2002·u2002Activity, thermostability and isozymes of superoxide dismutase (SOD) of 17 edible mushrooms from China were investigated in this study. The results indicated that most of these mushrooms have high SOD activities, especially Pleurotus citrinopileatus, Agaricus bisporus, Pleurotus ostreatus, Volvariella volvacea and Agrocybe aegerita, which contained SOD activities …

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  • Pre-emptive gene therapy using recombinant adeno ...

    At 6 weeks prior to myocardial injury, the human extracellular superoxide dismutase (Ec-SOD) gene was delivered by direct intramyocardial injections, using a …

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  • BLACKMORES Vitamins & Supplements - Australia's #1 ...

    Bovine sodium chondroitin sulfate: 400 mg. Glucosamine sulfate sodium chloride complex (glucosamine sulfate 750 mg): 942 mg. Manganese gluconate (manganese 1mg): 8.8 mg. Manganese is an essential trace mineral that is a co-factor in many of the body's enzymes, including superoxide dismutase.

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  • The anti-malarial drug atovaquone potentiates platinum ...

    2020-10-27u2002·u2002The superoxide dismutase mimetic MnTBAP rescues ATQ-induced mROS production and pre-loading cells with the GSH prodrug N-acetyl cysteine (NAC) abrogates the sensitization. ... ATQ has an excellent ...

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  • A Novel Bioengineered Material to Reverse Intervertebral ...

    A Novel Bioengineered Material to Reverse Intervertebral Disc Degeneration. Daisuke Fukui 1,2, Koichi Masuda 1, Michael Zimber 3, Stephanie Y. Adachi 1, Natsuko Arimoto 1, Jeong Ho Kim 3, Martin Latterich 3, Gail K. Naughton 3 *. 1 Department of Orthopaedic Surgery University of California, San Diego 9500 Gilman Drive La Jolla, CA 92093.

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  • Glycation vs. glycosylation: a tale of two different ...

    2016-6-21u2002·u2002In our previous studies, we reported that the activity of an anti-oxidant enzyme, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) became decreased as the result of glycation in vitro and in vivo. Glycated Cu,Zn-SOD produces hydroxyl radicals in the presence of transition metals due to the formation of a Schiff base adduct and a subsequent Amadori product. This results in the site …

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  • Exogenously-added copper/zinc superoxide dismutase rescues ...

    2011-10-18u2002·u2002Superoxide dismutase from bovine erythrocytes, Cu/Zn type (Cu/Zn SOD), was obtained from Wako Pure Chem. Ind. (Osaka, Japan). Specific activity was 2100 units/mg protein. MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, and PI3K inhibitor LY294002 were from Calbiochem-Novabiochem Corp. (San Diego, CA).

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  • mitochondrial superoxide reveal foetal endothelial ...

    ©The Japan Endocrine Society Original Alterations of transcriptome expression, cell cycle, and mitochondrial superoxide reveal foetal endothelial dysfunction in Saudi women with gestational diabetes mellitus Samar Sultan1), Farid Ahmed1), 2), Osama Bajouh3), 4), Hans-Juergen Schulten1), 2), Nadia Bagatian2),

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  • Superoxide dismutase activity of a novel macromolecular ...

    1999-5-1u2002·u2002The discovery of a novel superoxide dismutase (SOD) mimic which demonstrates SOD activity, chemical stability in H2O2 solution and long half‐life in circulation is reported. The SOD mimic consists of a manganese porphyrin (MnP) with SOD activity and a polymer (poly (styrene‐co‐maleic anhydride); SMA) with biological characteristics. The SOD activity of …

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  • Superoxide dismutase expression in the human corpus luteum ...

    2000-1-1u2002·u2002Changes in Cu,Zn-SOD activities (A) and Mn-SOD activities (B) in the human corpus luteum during the menstrual cycle and in early pregnancy.Samples were obtained from early luteal phase (days 1–5 of luteal phase with day 1 being the day of ovulation, n = 5), mid luteal phase (days 6–11, n = 6), late luteal phase (days 12–15, n = 5), regression phase (after onset of menstruation, …

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  • Chronic cardiotoxicity of doxorubicin involves activation ...

    2012-3-26u2002·u2002The data from measurements of superoxide dismutase activities, superoxide production and TAS were analyzed by one-way ANOVA. Differences were considered as significant at P <0.05 for all tests ...

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  • Advanced biomimetic nanoreactor for specifically killing ...

    2020-5-15u2002·u2002A superoxide anion biosensor based on direct electron transfer of superoxide dismutase on sodium alginate sol-gel film and its application to monitoring of living cells. Anal Chim Acta. 2012;717:61-6 47. Liu W, Ruan M, Wang Y, Song R, Ji X, Xu J. et al.

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  • Frontiers

    2021-5-28u2002·u2002Yeast-derived products containing β-glucans have long been used as feed supplements in domesticated animals in an attempt to increase immunity. β-glucans are mainly recognized by the cell surface receptor CLEC7A, also designated Dectin-1. Although the immune mechanisms elicited through Dectin-1 activation have been studied in detail in mice and humans, …

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  • superoxide dismutase type 2 diabetes ????insulin dependent

    superoxide dismutase type 2 diabetes ????events. Fasting Blood Glucose (FBG)-A FBG requires the patient not eat or drink (except water) anything for at least 8 hours before the test.This test is best done first thing in the morning. A person has diabetes …

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  • Wheat Qu and Its Production Technology, Microbiota, Flavor ...

    The traditional production technology used for raw wheat Qu is shown in Figure 2 (Mo et al., 2010; Wang, 2009; Zhang et al., 2012). This process is divided into the following six main steps: wheat crushing, adding water to wet the material, starter-treading and shaping, culturing in rooms, ventilating and drying, and storage.

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  • Kuwanon G protects HT22 cells from advanced glycation end ...

    The incidence of diabetic encephalopathy is increasing as the population ages. Evidence suggests that formation and accumulation of advanced glycation end products (AGEs) plays a pivotal role in disease progression, but limited research has been carried out in this area. A previous study demonstrated that Kuwanon G (KWG) had significant anti-oxidative stress and anti-inflammatory …

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  • The iron-dependent mitochondrial superoxide dismutase

    2017-7-21u2002·u2002Leishmaniasis is one of the leading globally neglected diseases, affecting millions of people worldwide. Leishmania infection depends on the ability of insect-transmitted metacyclic promastigotes to invade mammalian hosts, differentiate into amastigotes, and replicate inside macrophages. To counter the hostile oxidative environment inside macrophages, these …

    Get Price
  • Chimeric SOD2/3 inhibits at the endothelial-neutrophil ...

    2004-9-1u2002·u2002Superoxide dismutase 2/3 (SOD2/3) reduces intestinal blood flow during I/R. Animals were untreated (A) or treated with SOD2 (B) or SOD2/3 (C) 5 min before reperfusion. Intestinal blood flow was determined before ischemia (cont), during ischemia (isc), and 10, 30, and 60 min after reperfusion.

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  • Localization and Role of Manganese Superoxide

    2006-10-20u2002·u2002Abstract. Superoxide dismutase (SOD) catalyzes the transformation of superoxide to molecular oxygen and hydrogen peroxide. Of the four known SOD isoforms, distinguished by their metal cofactor (iron, manganese [Mn], copper/zinc, nickel), MnSOD is the dominant form in the diatom Thalassiosira pseudonana.We cloned the MnSOD gene, sodA, using the expression …

    Get Price
  • BLACKMORES Vitamins & Supplements - Australia's #1 ...

    Bovine sodium chondroitin sulfate: 400 mg. Glucosamine sulfate sodium chloride complex (glucosamine sulfate 750 mg): 942 mg. Manganese gluconate (manganese 1mg): 8.8 mg. Manganese is an essential trace mineral that is a co-factor in many of the body's enzymes, including superoxide dismutase.

    Get Price
  • A nanoselenium-coating biomimetic cytomembrane ...

    2021-7-30u2002·u2002The cell membrane is widely considered as a promising delivery nanocarrier due to its excellent properties. In this study, self-assembled Pseudomonas geniculate cell membranes were prepared with high yield as drug nanocarriers, and named BMMPs. BMMPs showed excellent biosafety, and could be more efficiently internalized by cancer cells than traditional red cell …

    Get Price
  • Ultrapure laser-synthesized Si-based nanomaterials for ...

    2016-5-6u2002·u2002In addition, we controlled oxidative stress markers, including blood catalase, superoxide dismutase, glutathione peroxidase, and serum vitamins A and E. As shown in Fig. 6, ALAT and catalase activities increased significantly 3 h after Si-NPs administration and then came back to normal 24 h after the injection (as compared to the control groups ...

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  • Antioxidants Mimic the Ability of Chorionic Gonadotropin ...

    1999-6-1u2002·u2002In the first set of experiments, healthy CL obtained from day 11 pseudopregnant rabbits were incubated in serum-free medium for 2 h in the absence or presence of superoxide dismutase (SOD; 1.5–150 U/ml), ascorbic acid (1–100 m m), N-acetyl-l-cysteine (25 and 50 m m), or catalase (10–1000 U/ml).

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  • Construction of mannose-modified polyethyleneimine

    2021-4-23u2002·u2002This study evaluated the D-mannose modified polyethyleneimine-block-polycaprolactone biomacromolecule copolymer micelles (PCL-PEI-mannose) as a targeted delivery of the glucocorticoid dexamethasone (DXM) to lung inflammation tissues and enhances the vehicle for its anti-inflammatory effects. Dexamethasone was encapsulated in the …

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  • A Novel Bioengineered Material to Reverse Intervertebral ...

    A Novel Bioengineered Material to Reverse Intervertebral Disc Degeneration. Daisuke Fukui 1,2, Koichi Masuda 1, Michael Zimber 3, Stephanie Y. Adachi 1, Natsuko Arimoto 1, Jeong Ho Kim 3, Martin Latterich 3, Gail K. Naughton 3 *. 1 Department of Orthopaedic Surgery University of California, San Diego 9500 Gilman Drive La Jolla, CA 92093.

    Get Price
  • Gold Nanozymes: From Concept to Biomedical

    2020-10-27u2002·u2002In recent years, gold nanoparticles have demonstrated excellent enzyme-mimicking activities which resemble those of peroxidase, oxidase, catalase, superoxide dismutase or reductase. This, merged with their ease of synthesis, tunability, biocompatibility and low cost, makes them excellent candidates when compared with biological enzymes for applications in …

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  • Chimeric SOD2/3 inhibits at the endothelial-neutrophil ...

    2004-9-1u2002·u2002Superoxide dismutase 2/3 (SOD2/3) reduces intestinal blood flow during I/R. Animals were untreated (A) or treated with SOD2 (B) or SOD2/3 (C) 5 min before reperfusion. Intestinal blood flow was determined before ischemia (cont), during ischemia (isc), and 10, 30, and 60 min after reperfusion.

    Get Price
  • Exogenously-added copper/zinc superoxide dismutase

    2011-10-18u2002·u2002Superoxide dismutase from bovine erythrocytes, Cu/Zn type (Cu/Zn SOD), was obtained from Wako Pure Chem. Ind. (Osaka, Japan). Specific activity was 2100 units/mg protein. MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, and PI3K inhibitor LY294002 were from Calbiochem-Novabiochem Corp. (San Diego, CA).

    Get Price
  • Important Role of Superoxide Dismutase in EDHF

    2020-6-18u2002·u2002Furthermore, we have recently demonstrated that in mouse mesenteric arteries, Cu,Zn-superoxide dismutase (SOD) plays an important role in synthesizing H 2 O 2 as an EDHF. 19 It has been reported that mitochondrial sources of H 2 O 2 play an important role in human coronary microvessels. 20 However, the role of SOD in the endothelial production ...

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  • Collagen Powder : Manufacturers, Suppliers, Wholesalers ...

    Derra Collagen was supplement product for Skin, hair, Nails . The main ingredient was 10000mg. of Salmon Collagen Peptide plus 10 Vitamin from Fruit who is Queen of Skin, Important of Vitamin from is Melon from France who has high SOD (Superoxide Dismutase ) who is the best for ANTI-OXIDANT. - Slow down old age.

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  • Metal interactions in mice under environmental stress ...

    2013-6-19u2002·u2002Analogously, Zn-binding biomolecules related to bovine serum albumin (Zn, Cu-BSA) and superoxide dismutase (Cu, Zn-SOD) at about 67 and 32 kDa, respectively, are induced in contaminated sites (Fig. 8c). Similarly, in kidney extracts can be also observed the presence of Cu-, Zn- and Cd-peaks at about 7 kDa, although the intensity is lower than ...

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  • NPC Natural Product Communications Vol. 12 No. 11 ...

    2021-7-8u2002·u20021794 Natural Product Communications Vol. 12 (11) 2017 Sugiura et al. Japanese Lessoniaceae (Laminariales, Phaeophyceae) including Ecklonia cava, Eck. kurome, Eck. stolonifera, Eisenia arborea, and Eis. bicyclis, and evaluated their inhibitory activities against the production of fluorescent AGEs in the serum albumin-MGO

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  • Frontiers

    2020-11-27u2002·u2002Many studies proposed that oxidative stress and apoptosis are key mechanisms in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). Xylose-pyrogallol conjugate (XP) is an original effective antioxidant that showed decent antioxidant and anti-apoptosis effect before. Thus the therapeutic effect and mechanism of XP in preventing CI-AKI in the short and long term were …

    Get Price
  • A nanoselenium-coating biomimetic cytomembrane ...

    2021-7-30u2002·u2002The cell membrane is widely considered as a promising delivery nanocarrier due to its excellent properties. In this study, self-assembled Pseudomonas geniculate cell membranes were prepared with high yield as drug nanocarriers, and named BMMPs. BMMPs showed excellent biosafety, and could be more efficiently internalized by cancer cells than traditional red cell membrane …

    Get Price
  • Comparison of the protective effects of resveratrol and ...

    2020-6-1u2002·u2002Evidence indicates that early weaning predisposes piglets to intestinal oxidative stress and increases the risk of intestinal dysfunction; however, there are minimal satisfactory treatment strategies for these conditions. This study investigated the potential of resveratrol and its analog, pterostilbene, as antioxidant protectants for regulating intestinal morphology, barrier function, and ...

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  • Joe V. Bannister's research works

    Joe V. Bannister's 40 research works with 1,231 citations and 2,820 reads, including: Metal ion activation of dioxygen: Edited by T G Spiro. pp 247. John Wiley & Sons, Chichester, UK. 1980. £16 ...

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  • Cu/Zn superoxide dismutase (SOD1) induction is

    2012-6-1u2002·u2002Cells were exposed to 4 mM ASA at different times (12–72 h), and pyrrolidine dithiocarbamate (PDTC) was used as an antioxidant control. Reactive oxygen species (ROS) production, oxidized protein levels, cytosolic superoxide dismutase (Cu/Zn-SOD), and glutathione peroxidase (GPx) activity were measured to evaluate oxidative stress.

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  • Chimeric SOD2/3 inhibits at the endothelial-neutrophil ...

    2004-9-1u2002·u2002Superoxide dismutase 2/3 (SOD2/3) reduces intestinal blood flow during I/R. Animals were untreated (A) or treated with SOD2 (B) or SOD2/3 (C) 5 min before reperfusion. Intestinal blood flow was determined before ischemia (cont), during ischemia (isc), and 10, 30, and 60 min after reperfusion.

    Get Price
  • Rosuvastatin restores superoxide dismutase expression

    2009-1-29u2002·u2002Rosuvastatin lowered the plaque volume, inhibited macrophage, lipid and oxLDL accumulation, and decreased the oxLDL-to-LDL ratio of plaques in the aortic arch. It increased superoxide dismutase 1 (SOD1), CD36, LXR-α, ABCA-1 and PPAR-γ RNA expression in aortic extracts. SOD1 was the strongest inverse correlate of oxLDL.

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  • The iron-dependent mitochondrial superoxide dismutase

    2017-7-21u2002·u2002Leishmaniasis is one of the leading globally neglected diseases, affecting millions of people worldwide. Leishmania infection depends on the ability of insect-transmitted metacyclic promastigotes to invade mammalian hosts, differentiate into amastigotes, and replicate inside macrophages. To counter the hostile oxidative environment inside macrophages, these protozoans contain anti-oxidant ...

    Get Price
  • Localization and Role of Manganese Superoxide

    2006-10-20u2002·u2002Abstract. Superoxide dismutase (SOD) catalyzes the transformation of superoxide to molecular oxygen and hydrogen peroxide. Of the four known SOD isoforms, distinguished by their metal cofactor (iron, manganese [Mn], copper/zinc, nickel), MnSOD is the dominant form in the diatom Thalassiosira pseudonana.We cloned the MnSOD gene, sodA, using the expression vector pBAD, …

    Get Price
  • Frontiers

    2020-11-27u2002·u2002Many studies proposed that oxidative stress and apoptosis are key mechanisms in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). Xylose-pyrogallol conjugate (XP) is an original effective antioxidant that showed decent antioxidant and anti-apoptosis effect before. Thus the therapeutic effect and mechanism of XP in preventing CI-AKI in the short and long term were …

    Get Price
  • Effect of Blueberry Anthocyanins Malvidin and Glycosides ...

    The objective of this research was to survey the antioxidant functional role of the main anthocyanins of blueberries in endothelial cells. Changes on the reactive oxygen species (ROS), xanthine oxidase-1 (XO-1), superoxide dismutase (SOD), and heme oxygenase-1 (HO-1) in cells of malvidin and the two glycosides were investigated. The results showed that these anthocyanins decreased the levels ...

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  • A nanoselenium-coating biomimetic cytomembrane ...

    2021-7-30u2002·u2002The cell membrane is widely considered as a promising delivery nanocarrier due to its excellent properties. In this study, self-assembled Pseudomonas geniculate cell membranes were prepared with high yield as drug nanocarriers, and named BMMPs. BMMPs showed excellent biosafety, and could be more efficiently internalized by cancer cells than traditional red cell membrane …

    Get Price
  • A Novel Bioengineered Material to Reverse Intervertebral ...

    A Novel Bioengineered Material to Reverse Intervertebral Disc Degeneration. Daisuke Fukui 1,2, Koichi Masuda 1, Michael Zimber 3, Stephanie Y. Adachi 1, Natsuko Arimoto 1, Jeong Ho Kim 3, Martin Latterich 3, Gail K. Naughton 3 *. 1 Department of Orthopaedic Surgery University of California, San Diego 9500 Gilman Drive La Jolla, CA 92093.

    Get Price
  • Antioxidative and Antihypertensive Effects of Welsh Onion ...

    Abstract. The effects of Welsh onion on the development of hypertension and autoxidation were studied in 6-week-old male Sprague-Dawley rats. The rats were fed with a control diet or a high-fat high-sucrose (HFS) diet with or without 5% Welsh onion (green-leafy type or white-sheath type) for 4 weeks.

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  • Mesenchymal Stem Cell Therapy Protects Lungs from ...

    2017-4-10u2002·u2002Treatment with superoxide dismutase mimetic (EUK134) counteracts radiation-induced EC loss. To investigate whether restoration of SOD1 may contribute to the protective MSC action and counteract the RT-induced EC loss as an adverse late effect, we applied the superoxide dismutase mimetic EUK134 during the first 3 weeks postirradiation.

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  • Use of superoxide dismutase and catalase producing lactic ...

    Superoxide dismutase (SOD) producing Lactobacillus casei BL23 was able to significantly attenuate the TNBS-induced damages in mice as shown by higher survival rates, decreased animal weight loss ...

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  • Babao Dan attenuates acute ethanol-induced liver injury ...

    2019-10-1u2002·u2002Babao Dan (BBD), a traditional Chinese medicine, has been used as a complementary and alternative medicine to treat multifarious liver diseases. In this study, we aimed to observe its protective effect on ethanol-induced liver injury and explore potential mechanisms. Mice pretreated with BBD (0.125, 0.25 and 0.5 g/kg BW) were administrated by ethanol gavage (5 g/kg BW).

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  • Fullerene derivatives protect endothelial cells against NO ...

    2020-4-5u2002·u2002there is a little evidence concerning whether there is a direct correlation between their ROS scavenging activity and their NO-removing capacity. According to Satoh et al [11], the inhibitory effect of malonic acid C 60 on NO-induced relaxation of rabbit aorta could be masked in the presence of superoxide dismutase (SOD).

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  • Amelioration of ulcerative colitis via inflammatory ...

    2020-8-8u2002·u2002Similarly, the hydrogen peroxide (H 2 O 2) and superoxide levels, as direct indicators of ROS, in the RMN treated group were also the lowest compared to other colitis groups (Figure 4D-E). Moreover, the therapeutic effects against UC in mice were also investigated via examination of the histopathological changes of the colons.

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  • Photoactivable Polymers Embedded with Cadmium-Free

    2021-3-12u2002·u2002The rising incidence of antibiotic-resistant infections from contaminated surfaces in hospitals or implanted medical devices has led to increasing interest in new antibacterial surfaces. Photoactivatable surfaces that can generate cytotoxic reactive oxygen species under exposure to ambient light is a promising approach to inactivation of surface-borne microorganisms. There is growing interest ...

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  • Polymeric Crowding Agents Improve Passive

    2019-12-12u2002·u2002Large solutes such as high molecular weight proteins can be difficult to encapsulate in lipid vesicles. Passive trapping of these macromolecular solutes during vesicle formation typically results in concentrations inside the vesicles that are much lower than in the external solution. Here, we investigated the effect of macromolecular crowding on passive encapsulation of biological ...

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  • Enzymes for pharmaceutical and therapeutic applications ...

    2020-4-5u2002·u2002Enzymes are highly efficient and selective biocatalysts, present in the living beings. They exist in enormous varieties in terms of the types of reactions catalyzed by them for instance oxidation–reduction, group transfers within the molecules or between the molecules, hydrolysis, isomerization, ligation, bond cleavage, and bond formation.

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  • superoxide dismutase type 2 diabetes ????insulin dependent

    superoxide dismutase type 2 diabetes ????events. Fasting Blood Glucose (FBG)-A FBG requires the patient not eat or drink (except water) anything for at least 8 hours before the test.This test is best done first thing in the morning. A person has diabetes if their FBG is greater than or equal to 126 mg/dl.

    Get Price
  • Plasma-activated water: generation, origin of reactive ...

    2020-5-19u2002·u2002Plasma, the fourth fundamental state of matter after solid, liquid and gas, is an electrically conducting medium, rich in unbound positive and negative ions, numerous reactive radicals, quanta of electromagnetic radiation and strong electric fields [1–3].Plasmas are broadly classified into two main groups on the basis of thermodynamic temperature equilibrium of the constituents, viz. thermal ...

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